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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1957 2
1958 2
1963 6
1964 13
1965 12
1966 4
1967 7
1968 28
1969 34
1970 21
1971 40
1972 30
1973 52
1974 35
1975 52
1976 33
1977 38
1978 38
1979 37
1980 48
1981 47
1982 47
1983 51
1984 67
1985 76
1986 70
1987 67
1988 58
1989 83
1990 89
1991 81
1992 100
1993 93
1994 101
1995 104
1996 96
1997 110
1998 87
1999 107
2000 105
2001 118
2002 106
2003 111
2004 103
2005 205
2006 219
2007 206
2008 188
2009 183
2010 182
2011 208
2012 204
2013 185
2014 180
2015 170
2016 150
2017 113
2018 165
2019 144
2020 157
2021 137
2022 119
2023 103
2024 34

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5,426 results

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Page 1
The pentose phosphate pathway in health and disease.
TeSlaa T, Ralser M, Fan J, Rabinowitz JD. TeSlaa T, et al. Nat Metab. 2023 Aug;5(8):1275-1289. doi: 10.1038/s42255-023-00863-2. Epub 2023 Aug 23. Nat Metab. 2023. PMID: 37612403 Review.
The pentose phosphate pathway (PPP) is a glucose-oxidizing pathway that runs in parallel to upper glycolysis to produce ribose 5-phosphate and nicotinamide adenine dinucleotide phosphate (NADPH). Ribose 5-phosphate is used for nucl …
The pentose phosphate pathway (PPP) is a glucose-oxidizing pathway that runs in parallel to upper glycolysis to produce ribose 5-p …
Mitochondrial NADP(H) generation is essential for proline biosynthesis.
Zhu J, Schwörer S, Berisa M, Kyung YJ, Ryu KW, Yi J, Jiang X, Cross JR, Thompson CB. Zhu J, et al. Science. 2021 May 28;372(6545):968-972. doi: 10.1126/science.abd5491. Epub 2021 Apr 22. Science. 2021. PMID: 33888598 Free PMC article.
The coenzyme nicotinamide adenine dinucleotide phosphate (NADP(+)) and its reduced form (NADPH) regulate reductive metabolism in a subcellularly compartmentalized manner. Mitochondrial NADP(H) production depends on the phosphorylation of …
The coenzyme nicotinamide adenine dinucleotide phosphate (NADP(+)) and its reduced form (NADPH) regulate …
Mitochondrial NADP(+) is essential for proline biosynthesis during cell growth.
Tran DH, Kesavan R, Rion H, Soflaee MH, Solmonson A, Bezwada D, Vu HS, Cai F, Phillips JA 3rd, DeBerardinis RJ, Hoxhaj G. Tran DH, et al. Nat Metab. 2021 Apr;3(4):571-585. doi: 10.1038/s42255-021-00374-y. Epub 2021 Apr 8. Nat Metab. 2021. PMID: 33833463 Free PMC article.
Nicotinamide adenine dinucleotide phosphate (NADP(+)) is vital to produce NADPH, a principal supplier of reducing power for biosynthesis of macromolecules and protection against oxidative stress. NADPH exists in separate pools, in both the cytos …
Nicotinamide adenine dinucleotide phosphate (NADP(+)) is vital to produce NADPH, a principal supplier of …
NADPH and Mitochondrial Quality Control as Targets for a Circadian-Based Fasting and Exercise Therapy for the Treatment of Parkinson's Disease.
Curtis WM, Seeds WA, Mattson MP, Bradshaw PC. Curtis WM, et al. Cells. 2022 Aug 4;11(15):2416. doi: 10.3390/cells11152416. Cells. 2022. PMID: 35954260 Free PMC article. Review.
Here, we discuss how intermittent fasting from the evening meal through to the next-day lunch together with morning exercise, when circadian NAD(+)/NADH is most oxidized, circadian NADP(+)/NADPH is most reduced, and circadian mitophagy gene expression is high, may slow the …
Here, we discuss how intermittent fasting from the evening meal through to the next-day lunch together with morning exercise, when circadian …
A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway.
Ghergurovich JM, García-Cañaveras JC, Wang J, Schmidt E, Zhang Z, TeSlaa T, Patel H, Chen L, Britt EC, Piqueras-Nebot M, Gomez-Cabrera MC, Lahoz A, Fan J, Beier UH, Kim H, Rabinowitz JD. Ghergurovich JM, et al. Nat Chem Biol. 2020 Jul;16(7):731-739. doi: 10.1038/s41589-020-0533-x. Epub 2020 May 11. Nat Chem Biol. 2020. PMID: 32393898 Free PMC article.
Glucose is catabolized by two fundamental pathways, glycolysis to make ATP and the oxidative pentose phosphate pathway to make reduced nicotinamide adenine dinucleotide phosphate (NADPH). The first step of the oxidative pentose phosphate …
Glucose is catabolized by two fundamental pathways, glycolysis to make ATP and the oxidative pentose phosphate pathway to make reduce …
NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism.
Chen L, Zhang Z, Hoshino A, Zheng HD, Morley M, Arany Z, Rabinowitz JD. Chen L, et al. Nat Metab. 2019 Mar;1:404-415. Epub 2019 Mar 11. Nat Metab. 2019. PMID: 31058257 Free PMC article.
NADPH donates high energy electrons for antioxidant defense and reductive biosynthesis. Cytosolic NADP is recycled to NADPH by the oxidative pentose phosphate pathway (oxPPP), malic enzyme 1 (ME1) and isocitrate dehydrogenase 1 (IDH1). ...Loss of G6PD results in hig …
NADPH donates high energy electrons for antioxidant defense and reductive biosynthesis. Cytosolic NADP is recycled to NADPH by the ox …
Chemo-enzymatic synthesis of adenine substituted nicotinic acid adenine dinucleotide phosphate (NAADP) analogs.
Su P, Bretz JD, Gunaratne GS, Marchant JS, Walseth TF, Slama JT. Su P, et al. Bioorg Med Chem. 2021 Jan 15;30:115901. doi: 10.1016/j.bmc.2020.115901. Epub 2020 Dec 1. Bioorg Med Chem. 2021. PMID: 33321420 Free PMC article.
Nicotinamide adenine dinucleotide phosphate (NADP) is an indispensable metabolic co-substrate and nicotinic acid adenine dinucleotide phosphate (NAADP) is an important Ca(2+) releasing intracellular second messenger. ...The …
Nicotinamide adenine dinucleotide phosphate (NADP) is an indispensable metabolic co-substrate and nicotin …
LRRK2 is required for CD38-mediated NAADP-Ca2+ signaling and the downstream activation of TFEB (transcription factor EB) in immune cells.
Nabar NR, Heijjer CN, Shi CS, Hwang IY, Ganesan S, Karlsson MCI, Kehrl JH. Nabar NR, et al. Autophagy. 2022 Jan;18(1):204-222. doi: 10.1080/15548627.2021.1954779. Epub 2021 Jul 27. Autophagy. 2022. PMID: 34313548 Free PMC article.
The common pathogenic mutant, LRRK2(G2019S), appears to hijack this pathway.Abbreviations:ADPR: ADP-ribose; AMPK: AMP-activated protein kinase; BMDM: bone marrow-derived macrophage; cADPR: cyclic-ADP-ribose; COR: C-terminal of ROC; CTSD: cathepsin D; ECAR: extracellular acidifica …
The common pathogenic mutant, LRRK2(G2019S), appears to hijack this pathway.Abbreviations:ADPR: ADP-ribose; AMPK: AMP-activated protein kina …
carba Nicotinamide Adenine Dinucleotide Phosphate: Robust Cofactor for Redox Biocatalysis.
Zachos I, Döring M, Tafertshofer G, Simon RC, Sieber V. Zachos I, et al. Angew Chem Int Ed Engl. 2021 Jun 21;60(26):14701-14706. doi: 10.1002/anie.202017027. Epub 2021 May 10. Angew Chem Int Ed Engl. 2021. PMID: 33719153 Free PMC article.
Here we report a new robust nicotinamide dinucleotide phosphate cofactor analog (carba-NADP(+) ) and its acceptance by many enzymes in the class of oxidoreductases. Replacing one ribose oxygen with a methylene group of the natural NADP(+) was fo …
Here we report a new robust nicotinamide dinucleotide phosphate cofactor analog (carba-NADP(+) ) and its accepta …
NAADP-binding proteins find their identity.
Marchant JS, Gunaratne GS, Cai X, Slama JT, Patel S. Marchant JS, et al. Trends Biochem Sci. 2022 Mar;47(3):235-249. doi: 10.1016/j.tibs.2021.10.008. Epub 2021 Nov 20. Trends Biochem Sci. 2022. PMID: 34810081 Free PMC article. Review.
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger that releases Ca(2+) from endosomes and lysosomes by activating ion channels called two-pore channels (TPCs). ...
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger that releases Ca(2+) from endosomes and lys …
5,426 results